The M2 is featured in Call of Duty: United Offensive. At the start of the game, the player uses an M2 that's mounted on a Jeep against enemies while trying to get back to base. While ineffective against tanks, it can destroy trucks in a few shots.
Later on, multiple M2s are used aboard a B-17 Flying Fortress against enemy planes. At first, the player is forced to use specific ones, but by the end, the player can choose whichever one he/she want to use.
In Multiplayer, the Jeep and the M4 Sherman tank are equipped with an M2. It can be used by entering the vehicle, then wheel-scrolling to another position.
In Call of Duty: Finest Hour, the M2 appears in the British campaign. It is mounted on a jeep and is used for most of the level "A Desert Ride". It is seen on jeeps in the level "Matmata", but they use the MG42 sound effects.
In Call of Duty: Roads to Victory , the M2 Browning can be found on a number of occasions. Several Brownings are mounted on the B-24 Liberator in Lucky Thirteen, as well as mounted on M4 Shermans. The M2 is the player's main defense during the last battle of the second American mission and is also found in the third Canadian mission, when it is used to destroy several German half-tracks .
The M2 has a downside, as due to its high rate of fire and tendency to be used against vehicles, the M2 can ruin a player's accuracy count when fired too much.
The M2 makes one appearance in Call of Duty 3campain, at the start of the level "Falaise Road". It has unlimited ammo, but poor accuracy and a low rate of fire.
It also makes an apearence in Call of Duty 3 multiplayer on the back of american jeeps and all tanks. It has unlimited ammo. It is one of the most favored weapons to use but with the draw back of being vulnerable to snipers and some would rather drive. You can not aim down sights in this game.
The M2 makes a reappearance in Call of Duty 4: Modern Warfare. In "Charlie Don't Surf", two enemies will do a drive-by against the player with an M2 on a truck. If he's not killed, his truck will drive further into an enemy territory, where it's abandoned away in a corner. They can also be seen in the beginning of the mission while the player is on the helicopter. The M2 cannot be used if the player manages to get close to it. However, in the same mission, by getting out of the map and past the broadcast center (see glitch page for details) there is a lone M2. The M2's existence here is explained by a Technical located next to it at the beginning of the mission. It is identical to the one described above; it fires at the the helicopters. Next to the truck is the M2. Although not mounted on anything, a "Press F/X/Square To Use" appears on the screen. By pressing the "use" button, the player can use the M2. There is also a picture glitch that when the player see the press button to enter it shows a mounted M249 SAW. The M2 is also mounted on the M1 Abrams seen throughout the USMC Campaign. The M2 also shows up on several multiplayer maps such as Countdown. They are mounted on destroyed Technicals, but cannot be used.
The M2 is seen on a Technical again, though this time it is usable.
A strange thing to note about this mounted machine gun is that the player cannot see the player's hands when operating it, similar to how the player's hands cannot be seen when they are using the Helicopter-mounted Vulcan Cannon during the campaign level "Of Their Own Accord" and the Special Ops mission "Big Brother". In the level Team Player, when using the HMMWV-mounted Minigun, the player's hands and arms are visible while operating the weapon, spooling the gun and holding the trigger button. Nothing on the player's person is visible while using the mounted M2, however, and even its butterfly-trigger mechanism is never seen pressed down to fire the weapon.
The M2 Browning appears in a few levels; it is seen in Crash Site in hands of the young front gunner in the PBR. It is also seen as the turret of certain M113s in the levels SOG and The Defector, Bottom Feeder's gunner is equipped with an M2 Heavy Browning. The M2 can also be seen on GMC1/2 trucks in the multiplayer map Hanoi.