The C-130 is seen in the following campaign missions:
In "Operation 40", the Op 40 have to escape in a C-130 through heavy gunfire on the airfield. After the plane begins to show damage on the runway, Mason jumps off the plane to take out trucks blocking the end of the runway, allowing it to take off.
In "S.O.G.", during the invasion of Khe Sanh, a landing C-130 is destroyed, almost killing Hudson and injuring the team.
In "Crash Site", the Russians use a C-130 to transport a load of Nova 6, which is later shot down by CIA. Although SOG reach the crash first, the hull is hit by a Spetsnaz Hind, causing the front to fall down a small cliff, injuring the team.
"This baby, it shits out a film canister 12 miles up, then a C-130 comes by and... pfft... snags it at about 30,000 feet"
— Frank Woods
The C-130 is briefly mentioned by Frank Woods in opening cutscene to level Pyrrhic Victory. However, the plane seen is a C-17 with propellers instead of turboprop engines. It can also be seen flying around the map during the mission Suffer With Me.