In Call of Duty: Black Ops II during the Grief mode of Zombies, they are in conflict with the CDC for survival after the aftermath of Richtofen's Grand Scheme.
In the Zombies mode of Call of Duty: Black Ops II, there are no heard quotes or communication between the four operatives.
They appear as men in black suits heavily resembling the SSA seen in the Call of Duty: Black Ops campaign mission "U.S.D.D.". They also resemble what the zombies turn into when hit with the V-R11 in Call of the Dead.