The DNA Bomb (or referred as "Manticore" by the Announcer) is a killstreak in Call of Duty: Advanced Warfare. It is based on Manticore, a bio-weapon that attacks the nerves that appears in the campaign. The killstreak is acquired once the player obtains a 30 gun kill streak. Once called in, a ten-second countdown will commence before a green gas will appear all over the map for a few seconds, then disperse. Much like the M.O.A.B. or K.E.M. Strike, every enemy player will be killed. Unlike the Tactical Nuke, M.O.A.B., and K.E.M. Strike, this streak requires a thirty gun streak instead of the traditional twenty-five regular kill streak, making it more difficult to obtain. It should also be noted that scorestreak kills do not count towards acquiring the DNA Bomb, and that the DNA Bomb will usually accumulate a large amount of points for the player, due to it killing the entire enemy team. This could potentially net the player another scorestreak.
- The timer in the bottom-left will be replaced by a ten-second timer to denote when the DNA Bomb is called in, instead of a countdown timer being added to the screen like with other scorestreaks.
- If the player looks at an enemy player killed by the DNA Bomb, they will be emitting green smoke, and there will be a green-ish pile of fluid under them.