General Diego Almagro was the secondary antagonist in Call of Duty: Ghosts. He was the original leader of the Federation during it's formation twelve years prior to the events of the game.

After General Almagro ordered the extermination or imprisonment of all U.S.-born individuals in the territories that are conquered by the Federation, the Ghosts' leader, Captain Gabriel Rorke convinced the U.S. leadership to send the Ghosts into Venezuela to assassinate Almagro in the hopes that this would lead to the collapse of the Federation. The Ghosts are successful in killing Almagro, but his death failed to halt the expansion of the Federation into a global superpower.

Additionally, Lieutenant Elias Walker was forced to abandon Rorke during the mission. This resulted in him being captured by the Federation and converted through the Amazonian torture techniques into a Federation field commander and the most dangerous threat that the Ghosts ever faced.

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