The dragons first appear as stone statues. Killing a zombie near the statue will cause it to burst open, revealing the dragon. After being activated, each dragon will have to eat approximately seven zombies. They eat the zombies one at a time, and the animation of eating a zombie has to finish before they will eat another. After the dragon is done, it will breathe a large amount of fire as ash forms around the dragon, and then reform back into the statue, which then crumbles to pieces, and reforms near the Wrath of the Ancient alter. This has to be done at each of the three locations to obtain the Wrath of the Ancients, located at:
- Eastern courtyard, above the entrance leading underground
- Church, mounted in the fireplace
- Pyramid room, on the southern wall
Dragon statues, as well as Dragon eggs, can also be seen in the corrupted Keeper boss fight of My brother's Keeper. Players can use the Dragon statues to hind from the electric attack of the corrupted keeper.
In the map Zetsubou No Shima, several blueprints describing Dragons and several devices able to control the Dragons can be seen. It is revealed that Group 935 and Division 9 have been collaborating on a research to resurrect ancient dragons, and in the same area where the blueprints can be found, there are remains of a dragon egg.
In Gorod Krovi, the Dragons return, this time as humongous abominations that can fly high into the sky and belch fire all around. They periodically blast fire on specific parts of the map, which can kill zombies and players alike. Players are immune to the fire if they are equipped with the Guard of Fafnir, however. Special dragons are also used to travel to the Pack-a-Punch Machine. To achieve this, players must first collect the three network circuits, which can be dropped by zombies after turning on the power, and then assign them to the corresponding Groph Module. This will allow a Drop Pod to land in a random part of the map, which the player has to protect from zombies until it's loaded up. Once done, the pod will open up, allowing the player to pick up the network circuit. The dragons will be available for 500 points once the three network circuits have been collected and deposited at the Operations Bunker's fuse box.
They are mentioned by Edward Richtofen in Blood of the Dead, confusing the Cerberus with a "Drachen". A dragon outline can also be seen the Ascension renewed loading screen from the Zombies Comics. Dragons are also mentioned in Shangri La, where the gongs around the map have the message "Beware the wrath of the dragon's fire". Furthermore, the Shisa figurines from the Ray Gun easter egg in the World At War Campaign are tied to dragons, as the legend says a Shisa figurine protected the Ryukyuans from a dragon.
Dragons return in the Dark Aether Story through Outbreak, where they function identically to their Der Eisendrache counterparts. Located at Dragon Relics that appear once in each map, players can begin a timed process for 500 points, during which zombies must be lured into a fire ring in which they shall be killed and fly into the dragon's mouth. Once time has run out, players are granted with a reward from a chest, with rarity scaling from low to high, depending on the amount of zombies fed. During this, the Dragon retreats into its relic, then flies to the sky into a portal.
- The logo of Der Eisendrache itself is a head of a dragon. The name of a map is translated from German into "The Iron Dragon" (which is also a reference to the facility's rockets).
- In the multiplayer map Berserk, two Dragons can be seen flying around the giant Viking statues outside the map.
- In Die Rise, dragon sculptures are a prominent part of the easter egg High Maintenance, as they rocket off fireworks and light up the Polarization Device. The map also features the achievement Facing the Dragon and art containing dragons.