The Directorate for Inter-Services Intelligence (More commonly known as Inter-Services Intelligence or simply by its initials ISI) is the premier intelligence service for the Islamic Republic of Pakistan.
ISI operatives make an appearance in Call of Duty: Black Ops II in the campaign mission "Fallen Angel". Under the command of an unnamed ISI Leader and his rogue ISI soldiers ally themselves with Raul Menendez and Cordis Die. They are seen attacking David Mason's team.
- A sign can be seen on the arm of the ISI soldier. Curiously, this sign is exactly the same as the sign on the arms of Yemeni Army soldiers.
- When gibbed, ISI soldiers will occasionally shout, 'help me" in English. This trait is shared with the Menendez Cartel and the Colossus-disguised Mercs in "Karma".