In multiplayer, the M1 Bazooka is available from the start, and can be selected if the Launched basic training is used. It can kill anyone close to the exploding radius with one shot, but that radius is relatively small compared to the German counterpart, the Panzerschreck. Players using the Armored Division can survive a hit by 50%.
At range however, it fires at a straighter line than the Panzerschreck. It is therefore effective against scorestreaks, being able to take down the low-level ones with one shot.
The M1 Bazooka cannot be found naturally on any of the maps within Nazi Zombies but can be temporarily spawned in via the use of a M1 Bazooka Consumable which can be equipped prior to entering a match.