General Manuel Antonio Noriega Moreno is the former Commander of the Panamanian Defense Forces (PDF) and a major antagonist in Black Ops II. Depending on the player's actions, he serves as the secondary or teritary antagonist. He was the de facto military president of Panama from 1983 to 1989.
He aids the CIA in capturing Raul Menendez by sending the PDF to his cartel's plantation in Nicaragua. The PDF capture him, but Noriega later betrays his own men by helping Menendez. Despite this, the drug lord nearly beats Noriega to death. He is the objective of Operation Just Cause, the United States invasion of Panama. Alex Mason and Frank Woods are sent to look for him in the outskirts of the Panama City. He is captured, but Jason Hudson later informs that he is an HVI and must be taken safely to a U.S. Army checkpoint for a 'prisoner exchange'. He later takes advantage of his captivity and throws Woods under the bus by capturing Alex Mason and placing a bag over his head so Woods would mistake him for Menendez. Noriega is last seen when Woods shoots Mason and finds out about the whole trick and attempts to shoot and kill Noriega only to get shot in the legs by Menendez. Throughout the mission he is codenamed "False Profit" by the CIA.
- Noriega can be briefly seen in the non-canonical ending when Avenged Sevenfold plays "Carry On".
- In July 2014, Manuel Noriega sued Activision over the use of his likeness without notifying him and portraying him as a villain. The suit was later dismissed by a California judge in October that year.