- "25 player killstreak earns a De-Atomizer Strike."
- — In-game description.
Nuclear is a Legendary gun perk in Call of Duty: Infinite Warfare, found upon certain weapon variants. It allows the player to earn a De-Atomizer Strike once they reach a 25 killstreak. Players are unable to earn a De-Atomizer Strike with other scorestreaks.
Nuclear also has a similar effect in Zombies mode. Once the player kills 150 zombies without being downed, a Nuke will spawn, ready for the player to collect.
Variants
| Weapon | Variant | Cost | Notes |
| NV4 | Fallout | 2000
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| R3K | Wasteland | N/A | Formerly exclusively unlocked via a supply drop. |
| KBAR-32 | Bunker Buster | 2000
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| Type-2 | Atomic | 2000
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| Mauler | Ruin | 2000
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| RPR Evo | Fission | 2000
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| EBR-800 | Purge | 2000
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| DCM-8 | Purifier | 2000
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| EMC | Calamity | 2000
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| Hailstorm | Culling | 2000
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| FHR-40 | Havoc | N/A | Unlocked via reaching level 40 with the Orion Initiative. |
| Karma-45 | Armaggedon | N/A | Unlocked via reaching level 20 with Blood Anvil. |
| HVR | Forsaken | N/A | Unlocked via reaching level 40 with Blood Anvil. |
| KBAR-32 | Igloo Buster | N/A | Unlocked on Day 12 of the 12 Days of Winter event. |
| Erad | Equniox | N/A | Unlocked via a Days of Summer Week #1 Supply Drop. |
| R.A.W. | Solar Powered | N/A | Unlocked via a Days of Summer Week #2 Supply Drop. |
| Auger | Abolisher | N/A | Unlocked via supply drops. |
| M.2187 | Graveyard | N/A | Unlocked via a Halloween Scream Week #1 Supply Drop. |