Safeguard can refer to:
- Safeguard (Soundtrack) - The fourteenth song in the Call of Duty: Modern Warfare 2 Soundtrack.
- Safeguard (Ghosts) - A game mode similar to Survival Mode in Call of Duty: Ghosts.
- Safeguard (Achievement) - An achievement in Call of Duty: Ghosts for the aforementioned game mode.
- Safeguard (game mode) - A game mode that first appeared in Call of Duty: Black Ops III.
- Safeguard (Special Ops Mission) - A Special Ops mission that appeared in Call of Duty: Modern Warfare (2019)
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